*lab member contributions are highlighted in bold

  1. Welter EM, Kosyk O, Zannas AS. An open access, machine learning pipeline for high-throughput quantification of cell morphology. STAR Protocols 2022; In press.

  2. Bey G, Pike J, Palta P, Zannas A, Xiao Q, Love SA, Heiss G. Biological Age Mediates the Effects of Perceived Neighborhood Problems on Heart Failure Risk Among Black Persons. J Racial Ethn Health Disparities 2022; In press. PMID: 36469285.

  3. Lu Y, Pike JR, Kucharska-Newton A, Palta P, Whitsel EA, Bey G, Zannas AS, Windham BG, Walker KA, Griswold M, Heiss G. Aging-related multisystem dysregulation over the adult lifespan and physical function in later life: the Atherosclerosis Risk in Communities (ARIC) Study. J Gerontol A Biol Sci Med Sci 2022; In press. PMID: 36453688.

  4. Leung CS, Kosyk O, Welter EM, Dietrich N, Archer TK, Zannas AS. Chronic stress-driven glucocorticoid receptor activation programs key cell phenotypes and functional epigenomic patterns in human fibroblasts. iScience 2022; 25(9):104960. PMID: 36065188.

  5. Zannas AS. Naturalistic Stress Hormone Levels Drive Cumulative Epigenomic Changes along the Cellular Lifespan. International Journal of Molecular Sciences 2021; 22(16):8778. PMID: 34445485.

  6. Palma-Gudiel H, Prather AA, Lin J, Oxendine JD, Guintivano J, Xia K, Rubinow DR, Wolkowitz O, Epel ES, Zannas AS. HPA axis regulation and epigenetic programming of immune-related genes in chronically stressed and non-stressed mid-life women. Brain, Behavior, and Immunity 2021; 92:49-56. PMID: 33221485.

  7. Zannas AS, Kosyk O, Leung CS. Prolonged Glucocorticoid Exposure Does Not Accelerate Telomere Shortening in Cultured Human Fibroblasts. Genes (Basel) 2020; 11(12):E1425. PMID: 33261163.

  8. Smith AK, Ratanatharathorn A, Maihofer AX, Naviaux RK, Aiello AE, Amstadter AB, Ashley-Koch AE, Baker DG, Beckham JC, Boks MP, Bromet E, Dennis M, Galea S, Garrett ME, Geuze E, Guffanti G, Hauser MA, Katrinli S, Kilaru V, Kessler RC, Kimbrel NA, Koenen KC, Kuan PF, Li K, Logue MW, Lori A, Luft BJ, Miller MW, Naviaux JC, Nugent NR, Qin X, Ressler KJ, Risbrough VB, Rutten BPF, Stein MB, Ursano RJ, Vermetten E, Vinkers CH, Wang L, Youssef NA; INTRuST Clinical Consortium; VA Mid-Atlantic MIRECC Workgroup; PGC PTSD Epigenetics Workgroup, Uddin M, Nievergelt CM. Epigenome-wide meta-analysis of PTSD across 10 military and civilian cohorts identifies methylation changes in AHRR. Nature Communications 2020; 11(1):5965. PMID: 33235198.

  9. Zannas AS, Gordon JL, Hinderliter AL, Girdler SS, Rubinow DR. IL-6 response to psychosocial stress predicts 12-month changes in cardiometabolic biomarkers in perimenopausal women. The Journal of Clinical Endocrinology and Metabolism 2020; 1;105(10):dgaa476. PMID: 32706883.

  10. Palma-Gudiel H, Fañanás L, Horvath S, Zannas AS. Psychosocial stress and epigenetic aging. International Review of Neurobiology 2020; 150:107-128. PMID: 32204828.

  11. Zannas AS, Stein MB, Chrousos GP. Editorial: Molecular mechanisms in stress and trauma related disorders. Frontiers in Psychiatry 2020; 11:103. PMID: 32194451.

  12. Linnstaedt SD, Zannas AS, McLean SA, Koenen KC, Ressler KJ. Literature review and methodological considerations for understanding circulating risk biomarkers following trauma exposure. Molecular Psychiatry 2019; In press. PMID: 31863020.

  13. Gassen NC, Niemeyer D, Muth D, Corman VM, Martinelli S, Gassen A, Hafner K, Papies J, Mösbauer L, Zellner A, Zannas AS, Herrmann A, Holsboer F, Brack-Werner R, Boshart M, Müller-Myhsok B, Drosten C, Müller MA, Rein T. SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection. Nature Communications 2019; 10(1):5770. PMID: 31852899.

  14. Zannas AS. Epigenetics as a key link between psychosocial stress and aging: concepts, evidence, mechanisms. Dialogues in Clinical Neuroscience 2019; 21(4):389-396. PMID: 31949406.

  15. Zannas AS. Decoding the life story of our epigenome. Epigenomics 2019; 11(11):1233-1236. PMID: 31490102.

  16. Zannas AS, Jia M, Hafner K, Baumert J, Wiechmann T, Pape JC, Arloth J, Ködel M, Martinelli S, Roitman M, Röh S, Haehle A, Emeny RT, Iurato S, Carrillo-Roa T, Lahti J, Räikkönen K, Eriksson JG, Drake AJ, Waldenberger M, Wahl S, Kunze S, Lucae S, Bradley B, Gieger C, Hausch F, Smith AK, Ressler KJ, Mueller-Myhsok B, Ladwig KH, Rein T, Gassen NC, Binder EB. Epigenetic upregulation of FKBP5 by aging and stress contributes to NF- κB-driven inflammation and cardiovascular risk. Proceedings of the National Academy of Sciences of the United States of America 2019; 116(23):11370-11379. PMID: 31113877.

  17. Palma-Gudiel H, Eixarch E, Crispi F, Morán S, Zannas AS, Fananas L. Prenatal adverse environment is associated with epigenetic age deceleration at birth and hypomethylation at the hypoxia-responsive EP300 gene. Clinical Epigenetics 2019; 11(1):73. PMID: 31072398.

  18. Rakesh G, Morey RA, Zannas AS, Malik Z, Marx C, Clausen AN, Kritzer MD, Szabo ST. Resilience as a Clinical Endpoint in the Treatment of PTSD. Molecular Psychiatry 2019; 24(9):1268-1283. PMID: 30867558.

  19. Pape JC, Carrillo-Roa T, Wiechmann T, Röh S, Rothbaum BO, Nemeroff CB, Czamara D, Zannas AS, Iosifescu D, Mathew SJ, Neylan TC, Mayberg HS, Dunlop BW, Binder EB. DNA methylation biomarkers of response to a CRF1 receptor antagonist for posttraumatic stress disorder. Clinical Epigenetics 2018; 10(1):136. PMID: 30390684.

  20. Zannas AS. Lithium treatment and mechanisms of aging. Molecular Psychiatry 2018; Molecular Psychiatry 2018; 23(11):2112-2113. PMID: 29422520.

  21. Zannas AS. Gene-environment interactions in late life: linking psychosocial stress with brain aging. Current Neuropharmacology 2018; 16(3):327-333. PMID: 29119927.

  22. Rakesh G, Szabo ST, Alexopoulos GS, Zannas AS. Strategies for dementia prevention: latest evidence and implications. Therapeutic Advances in Chronic Disease. 2017 Aug;8(8-9):121-136. PMID: 28815009.

  23. Emeny RT, Baumert J, Zannas AS, Kunze S, Wahl S, Iurato S, Arloth J, Erhardt A, Balsevich G, Schmidt MV, Weber P, Kretschmer A, Pfeiffer L, Kruse J, Strauch K, Roden M, Herder C, Koenig W, Gieger C, Waldenberger M, Peters A, Binder EB, Ladwig KH. Anxiety associated increased CpG methylation in the promoter of ASB1: evidence from the population-based KORA study, a clinical study and murine model. Neuropsychopharmacology 2018; 43(2):342-353. PMID: 28540928.

  24. Zannas AS, Chrousos GP. Epigenetic programming by stress and glucocorticoids along the human life span. Molecular Psychiatry 2017; 22(5):640-646. PMID: 28289275.

  25. Zannas AS, Kim, JH, West AE. Regulation and function of the methyl-DNA binding protein MeCP2 in corticolimbic brain regions during U50488-induced conditioned place aversion. Psychopharmacology 2017; 234(6):913-923. PMID: 28116477.

  26. Koudoumas D, Terrovitis J, Glentis P, Ntalianis A, Tsolakis E, Zannas AS, Tseliou E, Papalois A, Drakos S, Nanas JN. Comparison of two biventricular infarct patterns with respect to the infarct burden required to induce cardiogenic shock: an experimental study. Hellenic Journal of Cardiology 2017; 58(4):306-309. PMID: 27923684.

  27. Volk N, Pape JC, Engel M, Zannas AS, Cattane N, Cattaneo A, Binder EB, Chen A. Amygdalar microRNA-15a is essential for coping with chronic stress. Cell Reports 2016; 17(7):1882-1891. PMID: 27829158.

  28. Zannas AS, Balsevich G, Gassen NC. The emerging role of FKBP5 in the regulation of metabolism and body weight. Surgery for Obesity and Related Diseases 2016; 12(8):1560-1561. PMID: 27444859.

  29. Gassen NC, Chrousos GP, Binder EB, Zannas AS. Life stress, glucocorticoid signaling, and the aging epigenome: implications for aging-related disease. Neuroscience and Biobehavioral Reviews 2017; 74(Pt B):356-365. PMID: 27343999.

  30. Zannas AS. Freud and the human connectome. Acta Psychiatrica Scandinavica 2016; 134(3):275. PMID: 27252038.

  31. Zannas AS. Editorial perspective: Psychological stress and epigenetic aging: what can we learn and how can we prevent? Journal of Child Psychology and Psychiatry 2016; 57(6):674-5. PMID: 27192952.

  32. Kao CY, He Z, Zannas AS, Hahn O, Kühne C, Reichel JM, Binder EB, Wotjak CT, Khaitovich P, Turck CW. Fluoxetine treatment prevents the inflammatory response in a mouse model of posttraumatic stress disorder. Journal of Psychiatric Research 2016; 76:74-83. PMID: 26897419.

  33. Whelan CD, Hibar DP, van Velzen LS, Zannas AS, Carrillo-Roa T, McMahon K, Prasad G, Kelly S, Faskowitz J, deZubicaray G, Iglesias JE, van Erp TG, Frodl T, Martin NG, Wright MJ, Jahanshad N, Schmaal L, Sämann PG, Thompson PM. Heritability and reliability of automatically segmented human hippocampal formation subregions. Neuroimage 2016; 128:125-37. PMID: 26747746.

  34. Zannas AS, Arloth J, Carrillo-Roa T, Iurato S, Röh S, Ressler KJ, Nemeroff CB, Smith AK, Bradley B, Heim C, Lange JF, Brückl T, Ising M, Wray NR, Erhardt A, Binder EB, Mehta D. Lifetime stress accelerates epigenetic aging in an urban, African American cohort: relevance of glucocorticoid signaling. Genome Biology 2015; 16(1):266. PMID: 26673150.

  35. Gassen NC, Fries GR, Zannas AS, Rüegg J, Hartmann J, Zschocke J, Hafner K, Pfaffeneder T, Zimmermann SN, Knop M, Weber F, Kloiber S, Lucae S, Chrousos GP, Carell T, Ising M, Binder EB, Schmidt MV, Rein T. Chaperoning epigenetics: FKBP51 regulates DNMT1 phosphorylation and activity, impacting BDNF and antidepressant action. Science Signaling 2015; 8(404):ra119. PMID: 26602018.

  36. Zannas AS, Chrousos GP. Glucocorticoid signaling drives epigenetic and transcription factors to induce key regulators of human parturition. Science Signaling 2015; 8(400):fs19. PMID: 26508787.

  37. Zannas AS, Wiechmann T, Gassen NC, Binder EB. Gene-stress-epigenetic regulation of FKBP5: clinical and translational implications. Neuropsychopharmacology 2016; 41(1):261-74. PMID: 26250598.

  38. Zannas AS, Provencal N, Binder EB. Epigenetics of posttraumatic stress disorder: current evidence, challenges, and future directions. Biological Psychiatry 2015; 78(5):327-35. PMID: 25979620.

  39. Gassen NC, Hartmann J, Zannas AS, Zschocke J, Maccarrone G, Hafner K, Zellner A, Wagner KV, Mehta D, Kloiber S, Turck CW, Lucae S, Chrousos GP, Holsboer F, Binder EB, Ising M, Schmidt MV, Rein T. FKBP51 inhibits GSK3β and augments the effects of distinct psychotropic medications. Molecular Psychiatry 2016; 21(2):277-89. PMID: 25849320.

  40. Gaali S, Kirschner A, Cuboni S, Hartmann J, Kozany C, Balsevich G, Namendorf C, Sippel C, Zannas AS, Draenert R, Binder EB, Fernandez-Vizarra P, Almeida OFX, Rühter G, Uhr M, Schmidt MV, Touma C, Bracher A, Hausch F. Selective inhibitors for the psychiatric risk factor FKBP51 enabled by an induced-fit mechanism. Nature Chemical Biology 2015; 11(1):33-7. PMID: 25436518.

  41. Zannas AS, McQuoid DR, Payne ME, MacFall JR, Ashley-Koch A, Steffens DC, Potter GG, Taylor WD. Gene variants of the renin-angiotensin system are associated with accelerated hippocampal volume loss and cognitive decline in old age. American Journal of Psychiatry 2014; 171(11):1214-21. PMID: 25124854.

  42. Wijayatunge R, Chen LF, Cha YM, Zannas AS, Frank C, West AE. The histone lysine demethylase Kdm6b is required for activity-dependent preconditioning of hippocampal neuronal survival. Molecular and Cellular Neuroscience 2014; 61C:187-200. PMID: 24983519.

  43. Taylor WD, McQuoid DR, Payne ME, Zannas AS, MacFall JR, Steffens DC. Hippocampus atrophy and the longitudinal course of late-life depression. American Journal of Geriatric Psychiatry 2014; 22(12):1504-12. PMID: 24378256.

  44. Zannas AS, West AE. Epigenetics and the regulation of stress vulnerability and resilience. Neuroscience 2014; 264C:157-170. PMID: 24333971.

  45. Pelton GH, Andrews H, Roose SP, Marcus SM, D'Antonio K, Husn H, Petrella JR, Zannas AS, Doraiswamy PM, Devanand DP. Donepezil treatment of older adults with cognitive impairment and depression (DOTCODE study): clinical rationale and design. Contemporary Clinical Trials 2013; 37(2):200-8. PMID: 24315979.

  46. Zannas AS, Binder EB. Gene-environment interactions at the FKBP5 locus: sensitive periods, mechanisms and pleiomorphism. Genes Brain and Behavior 2014; 13(1):25-37. PMID: 24219237.

  47. Zannas AS, Okuno Y, Doraiswamy PM. Cholinesterase inhibitors and Pisa syndrome: a pharmacovigilance study. Pharmacotherapy 2014; 34(3):272-8. PMID: 24127392.

  48. Zannas AS, Doraiswamy PM, Shpanskaya KS, Murphy K, Petrella JR, Burke JR, Wong TZ. Impact of 18F-florbetapir PET imaging of beta-amyloid neuritic plaque density on clinical decision making. Neurocase 2014; 20(4):466-73. PMID: 23672654.

  49. Zannas AS, McQuoid DR, Payne ME, Steffens DC, MacFall JR, Ashley-Koch A, Taylor WD. Negative life stress and longitudinal hippocampal volume changes in older adults with and without depression. Journal of Psychiatric Research 2013; 47(6):829-834. PMID: 23478048.

  50. Zannas AS, Wong TZ, Doraiswamy PM. How much is a picture worth? Putting amyloid imaging to the test. Dementia and Geriatric Cognitive Disorders Extra 2012; 2:649-651. PMID: 23341830.

  51. Zannas AS, McQuoid DR, Steffens DC, Chrousos GP, Taylor WD. Stressful life events, perceived stress, and 12-month course off geriatric depression: direct effects and moderation by the 5-HTTLPR and COMT Val158Met polymorphisms. Stress 2012; 15(4):425-434. PMID: 22044241.

©Zannas Lab